胡应和（安徽绩溪宅坦村人）教授于1982年获中科院遗传所遗传学硕士，1990年获美国依阿华大学生物化学系博士，1990～1993年在哥伦比亚大学Eric R. Kandel（2000年Nobel 医学和生理学奖获得者）实验室做博士后。此后，曾任美国Genomics Institute of the Novartis Research Foundation研究员、Memory Pharmaceutical公司和美国Bayer 公司任科学家。2002年9月全职回国，任教育部 “脑功能基因组学重点实验室”主任，上海市“脑功能基因组学重点实验室”执行主任，华东师范大学“脑功能基因组学研究所”执行所长，华东师范大学“紫江特聘教授”,华东师范大学终身教授，教育部科技委员会委员，国家科技部“973计划”首席科学家，并先后主持两项科技部“863计划”项目。胡应和博士在脑功能基因组学研究领域有突出贡献，在《自然》、《神经元》《美国科学院院刊》等著名杂志发表论文多篇。
胡应和博士是国际上最早利用基因芯片等高新技术开展脑功能基因组学研究的科学家之一，对大脑活动和脑衰老过程中的基因表达图谱进行了深入研究，取得了重要进展，率先在《美国国家科学院学报》发表了两篇有关脑功能基因组图谱的研究论文。最近，他系统研究了PS1/PS2基因双敲除的老年痴呆症小鼠模型大脑基因表达变化，探讨老年痴呆的发病机理，发现了治疗老年痴呆症重要的药物靶标。
胡应和博士所领导的研究组进行脑功能基因组表达图谱、基因药靶、天然药物筛选分析、高通量药物筛选和新药的研究和开发工作，并获得美国和欧洲的发明专利多项。由于胡应和博士在脑功能基因组学研究和药物开发方面所取得的重要贡献，获得BAYER科学技术奖，MEMORY特殊贡献奖等多项奖励。美国的APPLIED GENOMICS AND PROTEIOMICS，CURRENT CHEMICAL BIOLOGY等杂志先后邀请他撰写有关中枢神经系统功能基因组学的权威性综述论文。
在蛋白质组学技术研究方面，胡应和博士创建的DPAS技术在国际上首次能够根据氨基酸序列来分析蛋白质，突破了过去针对每一个蛋白质都必须筛选其特异性配体的传统方法，使蛋白质芯片技术的研究产生了革命性的飞跃。由于DPAS技术的新颖性、高敏感性和特异性，能够精确检测细胞内微量蛋白质，并进行定量分析。因此利用DPAS技术，可以研制开发新一代蛋白质芯片，用于药物靶标的鉴定和临床诊断应用。对国家中长期规划中强调的蛋白质组学研究及靶标的发现具有重大推动作用。有关他的照片可在百度点击“胡应和”专条
发表的部分论文：
Hu, Y. and T. W. Conway. (1993) 2 Aminopurine inhibits the double-stranded RNA-dependent protein kinase both in vitro and in vivo. J. Interferon Res. 13: 323-328
Hu, Y., A. Barzilai, M. Chen, C. Bailey and E. R. Kandel (1993). 5-HT and cAMP induce the formation of coated pits and vesicles and increase the expression of clathrin light chain in sensory neurons of Aplysia. Neuron 10: 921-929
Zhuo, M., Y. Hu, C. Schultz, E. R. Kandel and R. D. Hawkins (1994). Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation. Nature 368: 635-639
Yamasaki, S., Y. Hu, T. Binz, A. Kalkuhl, H. Kurazono, T. Tamura, R. Jahn, E. R. Kandel and H. Niemann (1994). Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: Structure and proteolysis by tetanus toxin, and botulinal neurotoxins type D and F. Proc. Natl. Acad. Sci. U.S.A. 91: 4688-4692
Martin, K. C, Y. Hu, B. Armitage, S. A. Siegelbaum, E. R. Kandel and B-K Kaang. (1995). Evidence for synaptotagmin as an inhibitory clamp on synaptic vesicle release in Aplysia neurons. Proc. Natl. Acad. Sci. U. S. A. 92: 11307-11311 (First three authors made equal contributions)
Skehel. P. A., B. A. Armitage, D. Bartsch, Y. Hu, B-K Kaang, S.A. Siegelbaum, E. R. Kandel and K. C. Martin. (1995). Proteins functioning in synaptic transmission at the sensory to motor synapse of Aplysia. J. Neuropharmacology 34: 1379-1385
Hu, Y., B. T. Bloompuist, L. J. Cornfield, L. B. DeCarr, J. R. Flores-Riveros, L. Friedman, P. Jiang, L. Lewis-Higgins, Y. Sadlowski, J. Schaefer, N. Velazquez and M. L. McCaleb. (1996). Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J. Biol. Chem. 271: 26315-26319
Li, K., J. Zhang and Y. Hu. (1999). Targeting PKC-alpha for cancer gene therapy: effect of ISIS-3521. Current Opinion in Molecular Therapeutics 1: 393-398
Rampon, C., C. H. Jiang, H. Dong, D. J. Lockhart, P. G. Schultz, J. Z. Tsien and Y. Hu*. (2000). Effects of environmental enrichment on gene expression in the brain. Proc. Natl. Acad. Sci. U. S. A. 97: 12880-12884
Jiang, C. J., J. Z. Tsien, P.G. Schultz and Y. Hu*. (2001). The Effects of Aging on Gene Expression in the Hypothalamus and Cortex of Mice. Proc. Natl. Acad. Sci. U. S. A. 98: 1930-1934
Hu, Y. and Tsien J. Z. (2002). Functional Genomics: Profiling the Brain and Cognition with DNA Microarrays. Applied Genomics and Proteomics. 1 (4): 219-226
Wang D, Deng C, Bugaj-Gaweda B, Kwan M, Gunwaldsen C, Leonard C, Xin X, Hu Y, Unterbeck A, De Vivo. (2003) Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7. Cell Signal. 15 (9): 883-891
Hu Y. and Joe Z. Tsien (2003) Exploring the Brain Secret. Scientific American （Chinese Edition）10:50-54
Jiang C, Chen G, Zeng X, Ouyang K, Y. Hu*(2003) Generation of a bioactive neuropeptide in a cell-free system. Anal Biochem. 316(1):34-40
GAO Hong, OU-YANG Ke-Qing, ZHENG Xu-Xu, XU Zhi-Liang, Yinghe HU, CAI Shao-Xi. (2003) High throughput screening method of identifying agonist for muscarinic receptor. Chinese Pharmacological Bulletin. 19(7):776-779
XU Zhi-Liang, GAO Hong, OU-YANG Ke-Qing, ZHENG Xu-Xu, CAI Shao-Xi, Yinghe HU. (2003) Functional assay and high throughput screening for G-protein coupled receptors. Chinese Pharmacological Bulletin. 19(12):1330-1336
Zhang J, Meng B, Liao D, Zhou L, Zhang X, Chen L, Guo Z, Peng C, Zhu B, Lee PP, Xu X, Zhou T, Deng Z, Hu Y, Li K. (2003) De novo synthesis of PCR templates for the development of SARS diagnostic assay. Mol Biotechnol. 25(2):107-112
Zhi-liang XU, Hong GAO, Ke-qing OU-YANG, Shao-xi Cai, Y. Hu*. (2004) Establishment of a cell-based assay to screen regulators for Klotho gene promoter. Acta Pharmacologica Sini 25(9): 1165-1170
Xianchun Li, Y. Hu*. (2005) Gene expression profiling reveals the mechanism of action of anticonvulsant durg QYS. Brain Research Bulletin 66: 99-105
Xuxu Zheng, Yinghe Hu, Jianhui Liu and Keqing Ouyang. (2005) Screening of active compounds as neuromedin U2 receptor agonist from natural products. Bioorganic & Medicinal Chemistry Letters 15: 4531-4535
Bing Mei, Chunxia Li , Suzhen Dong, Cecilia H. Jiang, Huimin Wang, Y. Hu*. (2005) Distinct gene expression profiles in hippocampus and amygdala after fear conditioning. Brain Research Bulletin 67:1-12
Nan JIANG, Ke-qing OU-YANG, Shao-xi CAI, Yinghe HU, Zhi-liang XU. (2005) Identification of human dopamine D1-like receptor agonist using a cellbased functional assay. Acta Pharmacologica Sinica 26(10): 1181-1186
Xianchun Li, Hui Kuang, Nan Jiang, Y. Hu*. (2005) Involvement of Scn1b and Kcna1 ion channels in audiogenic seizures and PTZ-induced epilepsy. Epilepsy Research. 66:155-163
Zhen-Xia Qin, Feng Gu, Y. Hu*. (2005) Caspase-independent Prpgrammed Cell Death. Chinese Journal of Cell Biology. 27(3):277-280.
Xianchun Li, Qingxiong Yang , Y. Hu*. (2006) Regulation of the expression of GABAA receptor subunits by an antiepileptic drug QYS. Neuroscience Letters. 392:145-149
Huimin Wang, Y. Hu, Joe Z. Tsien.(2006) Molecular and Cellular Mechanisms of Memory Consolidation and Storage. Progress in Neurobiology. 2006 Jun;79(3):123-35.
Liwen Sun, Y. Hu*.(2006) Protective effects of EUK4010 on beta-Amyloid(1-42) induced degeneration of neuronal cells. European Journal of Neuroscience. 2006 Aug;24(4):1011-9.
Fang Liyan, Y. Hu* (2006) Chemical Genetic Analysis Reveals the Effects of NMU2R on the Expression of Peptide Hormones. Neuroscience Letters. 2006 Aug 14;404(1-2):148-53.
Bo Meng, Yue-woon Lui, Shi Meng, Changxiu Cao, Y. Hu*.(2006) Identification of Effective siRNA Blocking the Expression of SARS Viral Envelope E and RDRP Genes. Molecular Biotechnology. 2006 Jun;33(2):141-8.
Li C, Niu W, Jiang CH, Y. Hu*. (2007) Effects of enriched environment on gene expression and signal pathways in cortex of hippocampal CA1 specific NMDAR1 knockout mice. Brain Res Bull. 71(6):568-77.
Niu W, Jiang N, Y. Hu*. (2007) Detection of proteins based on amino acid sequences by multiple aptamers against tripeptides. Anal Biochem. 362(1):126-35.
Wang L, Bai J, Y. Hu*. (2007) Identification of the RA response element and transcriptional silencer in human alphaCaMKII promoter. Mol Biol Rep.2008,35 (1), 37-44
Dong SZ., P. Wu, CX Li, Y. Hu*. (2007) Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice. European Journal of Neuroscience. 26: 101-112.
Liu JH., F. Yin X. Zheng, J. Jing, Y. Hu (2007) Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway. Neurochemistry International. 51: 361-369
Qian Shen, Qiang Sun, Xiaoluan Wei, Juan Dong, Rong Zhang, Pu Wu, Yujuan Jin, Jie Feng, Houda Li and Yinghe Hu* (2007) Generation and Characterization of Islet Cell Tumor in pTet-on/pTRE-SV40Tag Double-Transgenic Mice Model. J. Biosci. Bioeng., 104, 14-21
Wu Pu , Shen Qian, Dong Suzhen, Hu Yinghe (2008), Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice ,Neurobiol Aging. 10:1502-11
Qin Zhenxia, Sun Zhongwei, Huang J, Hu Yinghe, Wu Zirong, Mei Bing (2008) Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-beta peptide (1-42)., Neurosci Lett. 444(3):217-221
Zheng Zhao and Yinghe Hu. (2008) Genome-wide expression profiles in amygdala and hippocampus in mice after fear conditioning. Handbook of Neurochemistry and Molecular Neurobiology (3rd Edition, Vol.13)
Zhu, M.-J., Sun, L.-J., Liu, Y.-Q., Feng, Y.-L., Tong, H.-T., Hu, Y.-H. and Zhao, Z. (2008) Blood F2-isoprostanes are significantly associated with the abnormalities of lipid status in rats with steatosis. World Journal of Gastroenterology 14: 4677-4683
Gu, F., Zhu, M.-J., Shi, J.-T., Hu, Y.-H. and Zhao, Z. (2008) Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice. Neuroscience Letters 440:44-48
Gu, F., Shi J.-T., Wen, Y., Fan, H., Hu, J.-F., Hu, Y.-H. and Zhao, Z. (2008) Translational responses of NR2B overexpression in the cerebral cortex of transgenic mice: a liquid chromatography-based proteomic approach. Brain Research doi:10.1016 /j.brainres. 2008.10.039
Zhu, M.-J., Gu, F., Shi, J.-T., Hu, J.-F., Hu, Y.-H. and Zhao, Z. (2008) Increased oxidative stress and astrogliosis responses in conditional double knockout mice of Alzheimer-like presenilin-1 and presenilin-2. Free Radic Biol Med 45(10):1493-1499
Wu SB., Zhao Y., Fan H., Hu YH., Hu J F., (2008) New Guaiane Sesquiterpenes and Furanocoumarins from Notopterygium incisum. Planta Medica, 74: 1812-1817.
Zhang Z., Wang D., Zhao,Y., Gao H., Hu, YH., Hu JF., (2008).Fructose-derived Carbohydrates from Alisma orientalis. Natural Product Research, in press
Wu SB, Yu YH., Hu YH., Hu, JF., (2008) A New Dimeric Furanocoumarin from Notopterygium incisum. Chin. Chem. Lett. 19: 940-942
Qiang Sun, Juan Dong, Wenting Yang, Yujuan Jin, Mingying Yang, Yan Wang, Philip L. Wang, Yinghe Hu, and Joe Z. Tsien (2008) Efficient reproduction of cynomolgus monkey using pronuclear embryo transfer technique. Proc. Natl. Acad. Sci. U. S. A. 105:12956-12960
Zai-xin Li, Ke-qing Ouyang, Xv Jiang, Dong Wang, and Yinghe Hu*, (2009) Curcumin Induces Apoptosis and Inhibits Growth of Human Burkitt’s Lymphoma in Xenograft Mouse Model. Mol. Cells OT, 283-289, DOI/ 10.1007/s10059-009-0036-9
Zhenxia Qin, Huiyan Zhu, Yinghe Hu* (2009). Effects of lysophosphatidylcholine on β-amyloid-induced neuronal apoptosis. Acta Pharmacologica Sinica (In Press)
[ 此贴被胡维平在2009-12-23 19:53重新编辑 ]
